OMass TherapeuticsPublications

Selected abstracts and publications from OMass and collaborators showcasing our cutting-edge science

Modular detergents tailor the purification and structural analysis of membrane proteins including G-protein coupled receptors

Leonhard H. Urner, Idlir Liko, Hsin-Yung Yen, Kin-Kuan Hoi, Jani Reddy Bolla, Joseph Gault, Fernando Gonçalves Almeida, Marc-Philip** Schweder, Denis Shutin, Svenja Ehrmann, Rainer Haag, Carol V. Robinson & Kevin Pagel

Modular detergents tailor the purification and structural analysis of membrane proteins including G-protein coupled receptors, Nature Communications, 564, 2020

PtdIns(4,5)P2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling

Hsin-Yung Yen, Kin Kuan Hoi, Idlir Liko, George Hedger, Michael R. Horrell, Wanling Song, Di Wu, Philipp Heine, Tony Warne, Yang Lee, Byron Carpenter, Andreas Plückthun, Christopher G. Tate, Mark S. P. Sansom & Carol V. Robinson

Nature 559, 423-427, 2018

Ligand binding to a G protein-coupled receptor captured in a mass spectrometer.

Yen HY, Hopper JTS, Liko I, Allison TM, Zhu Y, Wang D, Stegmann M, Mohammed S, Wu B, Robinson CV

Science Advances, 3, 2017

The role of interfacial lipids in stabilizing membrane protein oligomers

Kallol Gupta, Joseph A. C. Donlan, Jonathan T. S. Hopper, Povilas Uzdavinys, Michael Landreh, Weston B. Struwe, David Drew, Andrew J. Baldwin, Phillip J. Stansfeld & Carol V. Robinson

Nature, 541, 421-424, 2017

High-resolution mass spectrometry of small molecules bound to membrane proteins

Gault J, Donlan JA, Liko I, Hopper JT, Gupta K, Housden NG, Struwe WB, Marty MT, Mize T, Bechara C, Zhu Y, Wu B, Kleanthous C, Belov M, Damoc E, Makarov A, Robinson CV.

Nature Methods, 13, 333-336, 2016