OMass TherapeuticsPublications

Selected abstracts and publications from OMass and collaborators showcasing our cutting-edge science

PtdIns(4,5)P2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling

Hsin-Yung Yen, Kin Kuan Hoi, Idlir Liko, George Hedger, Michael R. Horrell, Wanling Song, Di Wu, Philipp Heine, Tony Warne, Yang Lee, Byron Carpenter, Andreas Plückthun, Christopher G. Tate, Mark S. P. Sansom & Carol V. Robinson

Nature 559, 423-427, 2018

Lipid binding attenuates channel closure of the outer membrane protein OmpF

Idlir Liko, Matteo T. Degiacomi, Sejeong Lee, Thomas D. Newport, Joseph Gault, Eamonn Reading, Jonathan T. S. Hopper, Nicholas G. Housden, Paul White, Matthew Colledge, Altin Sula, B. A. Wallace, Colin Kleanthous, Phillip J. Stansfeld, Hagan Bayley, Justin L. P. Benesch, Timothy M. Allison, and Carol V. Robinson

Proceedings of the National Academy of Sciences USA, 2018

Direct observation of the influence of cardiolipin and antibiotics on lipid II binding to MurJ

ani Reddy Bolla, Joshua B. Sauer, Di Wu, Shahid Mehmood, Timothy M. Allison & Carol V. Robinson

Nature Chemistry, 10, 363-371, 2018

Native Desorption Electrospray Ionization Liberates Soluble and Membrane Protein Complexes from Surfaces

Ambrose S, Housden NG, Gupta K, Fan J, White P, Yen HY, Marcoux J, Kleanthous C, Hopper JTS, Robinson CV

Angewandte Chemie, 56, 14463-14468, 2017

Ligand binding to a G protein-coupled receptor captured in a mass spectrometer.

Yen HY, Hopper JTS, Liko I, Allison TM, Zhu Y, Wang D, Stegmann M, Mohammed S, Wu B, Robinson CV

Science Advances, 3, 2017

The role of interfacial lipids in stabilizing membrane protein oligomers

Kallol Gupta, Joseph A. C. Donlan, Jonathan T. S. Hopper, Povilas Uzdavinys, Michael Landreh, Weston B. Struwe, David Drew, Andrew J. Baldwin, Phillip J. Stansfeld & Carol V. Robinson

Nature, 541, 421-424, 2017

Mass spectrometry guided structural biology

Idlir Liko, Timothy M Allison, Jonathan TS Hopper, Carol V Robinson

Current Opinion in Structural Biology, 40, 136-144, 2016

High-resolution mass spectrometry of small molecules bound to membrane proteins

Gault J, Donlan JA, Liko I, Hopper JT, Gupta K, Housden NG, Struwe WB, Marty MT, Mize T, Bechara C, Zhu Y, Wu B, Kleanthous C, Belov M, Damoc E, Makarov A, Robinson CV.

Nature Methods, 13, 333-336, 2016

Optimal Synthetic Glycosylation of a Therapeutic Antibody

Thomas B. Parsons, Weston B. Struwe, Joseph Gault, Keisuke Yamamoto, Thomas A. Taylor, Ritu Raj, Kim Wals, Shabaz Mohammed, Carol V. Robinson, Justin L. P. Benesch, Benjamin G. Davis

Angewandte Chemie, 55, 2361-2367, 2016

A subset of annular lipids is linked to the flippase activity of an ABC transporter

Bechara C, Nöll A, Morgner N, Degiacomi MT, Tampé R, Robinson CV

Nature Chemistry, 3, 255-265, 2015